DSIP
Delta Sleep-Inducing Peptide
Popular for:Sleep quality, stress reduction, pain modulation
0
Registered Trials
15
Trial Publications
346
PubMed References
Animal
Evidence Level
Overview
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino acid neuropeptide first isolated from rabbit brain in 1977 during sleep research. The short version: people usually care about it for sleep quality, stress reduction, pain modulation, but the strength of the evidence depends heavily on indication and study type.
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino acid neuropeptide first isolated from rabbit brain in 1977 during sleep research. It is named for its ability to promote slow-wave delta sleep, the deepest and most restorative phase of the sleep cycle.
DSIP crosses the blood-brain barrier and has been studied for its effects on sleep architecture, stress hormone modulation, and pain perception. Research has been conducted primarily in European academic institutions, with some clinical studies in humans demonstrating improved sleep efficiency and reduced sleep latency.
Research Snapshot
What the evidence says
AnimalDSIP currently shows 0 registered trials from ClinicalTrials.gov, 15 PubMed trial publications (5 RCT-tagged), and 346 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 0 registered trials are tracked from ClinicalTrials.gov intervention records.
- 15 PubMed clinical-trial publications are indexed.
- 5 PubMed randomized controlled trial publications are indexed.
- 346 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
DSIP modulates sleep architecture through multiple mechanisms: it influences serotonergic and GABAergic neurotransmission, reduces cortisol and CRH (corticotropin-releasing hormone) levels, and may affect melatonin secretion timing.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
0
Registered Trials
15
Trial Publications
5
RCT Publications
346
PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
0
Registered trials
15
Trial publications
5
RCT publications
346
PubMed references
10
Reviews
0
Meta-analyses
Registered trials source
Jun 1, 2026
DSIP, delta sleep-inducing peptide
Uses curated ClinicalTrials.gov intervention aliases to avoid misleading registry matches.
View sourceNot FDA-approved. Research compound. Studied in European academic settings since 1977. Some human clinical data available. Not scheduled.
Key PubMed References
346 PubMed references · showing top 25 by relevance
View all on PubMedsecreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.
Mu X, Qu L, Yin L, et al. · Frontiers in pharmacology · 2024
PMID: 39444618JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP.
Mikhaleva II, Prudchenko IA, Ivanov VT, et al. · Peptides · 2011
PMID: 21262293Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
Kovalzon VM, Strekalova TV · Journal of neurochemistry · 2006
PMID: 16539679[Hypnogenic properties of DSIP peptide analogs: structural-functional relationship].
Koval'zon VM · Izvestiia Akademii nauk. Seriia biologicheskaia · 2001
PMID: 11525128Characterization of the release and metabolism of delta sleep-inducing peptide (DSIP) in the rat brain.
Nakamura A, Nakanishi H, Shiomi H · Neuropeptides · 1993
PMID: 8474631Anecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for DSIP yet.
Side Effects & Safety
- Headache - Mild next-day grogginess (uncommon) - Injection site reactions - Limited standardization in available research compounds
Known Interactions
No curated interaction entry is live for DSIP yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.