Kisspeptin
Kisspeptin-10 · Kisspeptin-54 · KP-10 · Metastin
Popular for:Fertility treatment, hormone optimization, GnRH regulation, reproductive health
36
Registered Trials
60
Trial Publications
3,223
PubMed References
Phase III
Evidence Level
Overview
Kisspeptin is a neuropeptide that acts as the master regulator of the reproductive hormone axis. The short version: people usually care about it for fertility treatment, hormone optimization, gnrh regulation, reproductive health, but the strength of the evidence depends heavily on indication and study type.
Kisspeptin is a neuropeptide that acts as the master regulator of the reproductive hormone axis. Discovered in 2003, it stimulates GnRH (gonadotropin-releasing hormone) release from the hypothalamus, which triggers the cascade of LH and FSH secretion from the pituitary — the fundamental hormonal signals controlling reproduction.
Kisspeptin is being studied as a more physiological alternative to GnRH analogs in fertility treatments. Unlike GnRH agonists which can cause receptor desensitization, kisspeptin stimulates the natural GnRH pulse generator, potentially offering a safer approach to ovulation induction and IVF protocols.
Research Snapshot
What the evidence says
Phase IIIKisspeptin currently shows 36 registered trials from ClinicalTrials.gov, 60 PubMed trial publications (33 RCT-tagged), and 3,223 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 36 registered trials are tracked from ClinicalTrials.gov intervention records.
- 60 PubMed clinical-trial publications are indexed.
- 33 PubMed randomized controlled trial publications are indexed.
- 3,223 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
Kisspeptin binds to the GPR54 receptor (also called KISS1R) on GnRH neurons in the hypothalamus.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
36
Registered Trials
60
Trial Publications
33
RCT Publications
3,223
PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
36
Registered trials
60
Trial publications
33
RCT publications
3,223
PubMed references
734
Reviews
13
Meta-analyses
Registered trials source
Jun 1, 2026
Kisspeptin
Uses the exact compound name as a ClinicalTrials.gov intervention query.
View sourceNot FDA-approved. Active clinical trials at Imperial College London and other academic centers. Research compound. Strong pipeline for fertility applications.
Key PubMed References
3,223 PubMed references · showing top 25 by relevance
View all on PubMedInteractions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential.
Mills EG, Abbara A, Dhillo WS, et al. · Annals of the New York Academy of Sciences · 2024
PMID: 39269749Effects of kisspeptin on the maturation of human ovarian primordial follicles.
Rezaei-Tazangi F, Kooshesh L, Tayyebiazar A, et al. · Zygote (Cambridge, England) · 2024
PMID: 38099429Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.
Zhang J, Jin L, Kong L, et al. · Human reproduction (Oxford, England) · 2023
PMID: 37105233The role of kisspeptin in the pathogenesis of a polycystic ovary syndrome.
Aasif A, Alam R, Ahsan H, et al. · Endocrine regulations · 2023
PMID: 38127687The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.
Xie Q, Kang Y, Zhang C, et al. · Frontiers in endocrinology · 2022
PMID: 35837314Anecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for Kisspeptin yet.
Side Effects & Safety
- Headache - Hot flashes - Injection site reactions - Potential ovarian hyperstimulation in women (lower risk than GnRH analogs) - Limited long-term safety data for exogenous use
Known Interactions
No curated interaction entry is live for Kisspeptin yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.