NA-Semax Amidate
N-Acetyl Semax Amidate · NASA
Popular for:Enhanced cognitive version of Semax, longer-acting, BDNF stimulation
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Registered Trials
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Trial Publications
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PubMed References
Approved
Evidence Level
Overview
NA-Semax Amidate (N-Acetyl Semax Amidate) is a modified version of the Russian nootropic peptide Semax, with two chemical modifications: an N-terminal acetyl group and a C-terminal amide group. The short version: people usually care about it for enhanced cognitive version of semax, longer-acting, bdnf stimulation, but the strength of the evidence depends heavily on indication and study type.
NA-Semax Amidate (N-Acetyl Semax Amidate) is a modified version of the Russian nootropic peptide Semax, with two chemical modifications: an N-terminal acetyl group and a C-terminal amide group. These modifications increase the peptide's stability, bioavailability, and duration of action compared to standard Semax.
The acetylation protects against aminopeptidase degradation while the amidation protects against carboxypeptidase degradation, effectively shielding both ends of the peptide from enzymatic breakdown. This results in a longer-acting and more potent version that has become the preferred form in the Western research peptide community.
Research Snapshot
What the evidence says
ApprovedNA-Semax Amidate currently shows 0 registered trials from ClinicalTrials.gov, 0 PubMed trial publications (0 RCT-tagged), and 0 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 0 registered trials are tracked from ClinicalTrials.gov intervention records.
- 0 PubMed clinical-trial publications are indexed.
- 0 PubMed randomized controlled trial publications are indexed.
- 0 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
Like standard Semax, NA-Semax Amidate is a synthetic analog of ACTH (4-10) that stimulates BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor) expression.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
International Regulatory Status
Cognitive disorders (approved as parent compound Semax)
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Registered Trials
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Trial Publications
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RCT Publications
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PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
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Registered trials
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Trial publications
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RCT publications
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PubMed references
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Reviews
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Meta-analyses
Registered trials source
Jun 1, 2026
Semax
Uses curated ClinicalTrials.gov intervention aliases to avoid misleading registry matches.
View sourceNot FDA-approved. Modified version of Russian-approved Semax. Research compound. Popular in nootropics community as the preferred Semax variant.
Key PubMed References
No PubMed references matched the current source query for NA-Semax Amidate.
Check the PubMed queryAnecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for NA-Semax Amidate yet.
Side Effects & Safety
- Nasal irritation - Headache (usually resolves after first few days) - Mild anxiety in sensitive individuals (due to stimulating nature) - Insomnia if dosed too late in the day
Known Interactions
No curated interaction entry is live for NA-Semax Amidate yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.