Pinealon
EDR peptide · Glu-Asp-Arg
Popular for:Neuroprotection, sleep regulation, cognitive enhancement, Khavinson bioregulator
0
Registered Trials
1
Trial Publications
15
PubMed References
Approved
Evidence Level
Overview
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Khavinson as a bioregulator for the pineal gland and central nervous system. The short version: people usually care about it for neuroprotection, sleep regulation, cognitive enhancement, khavinson bioregulator, but the strength of the evidence depends heavily on indication and study type.
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Khavinson as a bioregulator for the pineal gland and central nervous system. It is designed to normalize pineal function and melatonin production, which decline significantly with age.
As a short-chain peptide (just 3 amino acids), Pinealon has the advantage of oral bioavailability — it can be taken as a capsule and still reach target tissues. This makes it one of the more accessible bioregulators. Research has focused on its neuroprotective effects and potential to improve sleep architecture in elderly subjects.
Research Snapshot
What the evidence says
ApprovedPinealon currently shows 0 registered trials from ClinicalTrials.gov, 1 PubMed trial publications (0 RCT-tagged), and 15 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 0 registered trials are tracked from ClinicalTrials.gov intervention records.
- 1 PubMed clinical-trial publications are indexed.
- 0 PubMed randomized controlled trial publications are indexed.
- 15 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
Pinealon penetrates cell membranes and interacts with DNA in pinealocytes (pineal gland cells) and neurons, modulating gene expression involved in circadian rhythm regulation and neuroprotection.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
International Regulatory Status
0
Registered Trials
1
Trial Publications
0
RCT Publications
15
PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
0
Registered trials
1
Trial publications
0
RCT publications
15
PubMed references
2
Reviews
0
Meta-analyses
Registered trials source
Jun 1, 2026
Pinealon
Uses the exact compound name as a ClinicalTrials.gov intervention query.
View sourceNot FDA-approved. Available as a supplement/bioregulator in some markets. Research compound. Part of the Khavinson peptide bioregulator family.
Key PubMed References
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
PMID: 41490200[Comparative analysis of different methods of geroprotective].
Myakotnykh VS, Torgashov MN, Egorin KV, et al. · Advances in gerontology = Uspekhi gerontologii · 2016
PMID: 28539017[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Meshchaninov VN, Tkachenko EL, Zharkov SV, et al. · Advances in gerontology = Uspekhi gerontologii · 2015
PMID: 26390612[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Mendzheritsky AM, Karantysh GV, Ryzhak GA, et al. · Advances in gerontology = Uspekhi gerontologii · 2015
PMID: 28509493[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, et al. · Advances in gerontology = Uspekhi gerontologii · 2014
PMID: 25051764Anecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for Pinealon yet.
Side Effects & Safety
- Generally well-tolerated - Mild GI discomfort (oral) - Very limited Western safety data - Long-term effects not fully characterized
Known Interactions
No curated interaction entry is live for Pinealon yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.