Pinealon
EDR peptide · Glu-Asp-Arg
Popular for:Neuroprotection, sleep regulation, cognitive enhancement, Khavinson bioregulator
15
Total Studies
8
Human Studies
Approved
Evidence Level
Not Approved
FDA Status
Overview
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Khavinson as a bioregulator for the pineal gland and central nervous system. It is designed to normalize pineal function and melatonin production, which decline significantly with age.
As a short-chain peptide (just 3 amino acids), Pinealon has the advantage of oral bioavailability — it can be taken as a capsule and still reach target tissues. This makes it one of the more accessible bioregulators. Research has focused on its neuroprotective effects and potential to improve sleep architecture in elderly subjects.
Mechanism of Action
Pinealon penetrates cell membranes and interacts with DNA in pinealocytes (pineal gland cells) and neurons, modulating gene expression involved in circadian rhythm regulation and neuroprotection. In the Khavinson bioregulator framework, short peptides like Pinealon act as epigenetic regulators, restoring gene expression patterns in specific tissues to more youthful configurations.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
International Regulatory Status
15
Total Studies
8
Human Studies
Not FDA-approved. Available as a supplement/bioregulator in some markets. Research compound. Part of the Khavinson peptide bioregulator family.
Key Studies / PubMed References
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
ReviewRahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
PMID: 41490200[Comparative analysis of different methods of geroprotective].
Human StudyMyakotnykh VS, Torgashov MN, Egorin KV, et al. · Advances in gerontology = Uspekhi gerontologii · 2016
PMID: 28539017[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Human StudyMeshchaninov VN, Tkachenko EL, Zharkov SV, et al. · Advances in gerontology = Uspekhi gerontologii · 2015
PMID: 26390612[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Animal StudyMendzheritsky AM, Karantysh GV, Ryzhak GA, et al. · Advances in gerontology = Uspekhi gerontologii · 2015
PMID: 28509493[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
In VitroMendzheritskiĭ AM, Karantysh GV, Ryzhak GA, et al. · Advances in gerontology = Uspekhi gerontologii · 2014
PMID: 25051764Side Effects & Safety
Known Interactions
No curated interaction entry is live for Pinealon yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Pinealon is not approved by the FDA for human therapeutic use. Always consult a qualified healthcare professional before making any health-related decisions. The studies referenced are linked to their original PubMed sources for verification.