Hexarelin

Examorelin

Growth HormoneNot ApprovedAnimalResearchSubQ

Popular for:Most potent GHRP, cardioprotective effects, GH secretion research

0

Registered Trials

58

Trial Publications

288

PubMed References

Animal

Evidence Level

Overview

Hexarelin is the most potent synthetic growth hormone releasing peptide, producing the largest GH pulses among the GHRP family. The short version: people usually care about it for most potent ghrp, cardioprotective effects, gh secretion research, but the strength of the evidence depends heavily on indication and study type.

Hexarelin is the most potent synthetic growth hormone releasing peptide, producing the largest GH pulses among the GHRP family. It is a hexapeptide that was developed as a research tool for studying maximum GH secretion capacity.

Due to its potency, Hexarelin also produces the most significant effects on cortisol and prolactin levels compared to other GHRPs. It is subject to rapid desensitization with continuous use, typically requiring cycling protocols in research settings.

Research Snapshot

What the evidence says

Animal

Hexarelin currently shows 0 registered trials from ClinicalTrials.gov, 58 PubMed trial publications (26 RCT-tagged), and 288 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.

Known vs uncertain

Known signals

  • 0 registered trials are tracked from ClinicalTrials.gov intervention records.
  • 58 PubMed clinical-trial publications are indexed.
  • 26 PubMed randomized controlled trial publications are indexed.
  • 288 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.

Open questions

  • Evidence strength may vary by indication, route, formulation, and population.
  • Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
  • Regulatory status and compounding access can change independently from the research literature.

Mechanism of Action

Hexarelin acts as a potent ghrelin receptor agonist at GHS-R1a, producing maximal stimulation of somatotroph cells.

Key Research Benefits

Most potent GH release of any GHRP
Studied for cardioprotective effects via CD36 receptor
Researched for maximum GH secretion testing
May support lean body mass research
Unique cardiac receptor interaction distinguishes it from other GHRPs

Clinical Evidence Summary

Research Pipeline

Preclinical
Animal
Phase I
Phase II
Phase III
Approved

0

Registered Trials

58

Trial Publications

26

RCT Publications

288

PubMed References

ClinicalTrials.govPubMed ESearchExact-name queryChecked May 3, 2026

Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.

0

Registered trials

58

Trial publications

26

RCT publications

288

PubMed references

22

Reviews

0

Meta-analyses

Registered trials source

Jun 1, 2026

Hexarelin

Uses the exact compound name as a ClinicalTrials.gov intervention query.

View source

Publication counts source

May 3, 2026

Hexarelin

Uses the exact display name.

View source

Not FDA-approved. Research compound. Primarily used in clinical research for GH secretion studies and cardiac research.

Key PubMed References

288 PubMed references · showing top 25 by relevance

View all on PubMed

Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein.

In Vitro

Meanti R, Licata M, Rizzi L, et al. · International journal of molecular sciences · 2023

PMID: 36674509

Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway.

In Vitro

Guan C, Li C, Shen X, et al. · European journal of medical research · 2023

PMID: 37710348

Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats.

Animal Study

Baser T, Ozdemir E, Filiz AK, et al. · Canadian journal of physiology and pharmacology · 2021

PMID: 32893668

Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats.

Animal Study

Agbo E, Liu D, Li M, et al. · Turkish journal of medical sciences · 2019

PMID: 31091855

The Safety and Efficacy of Growth Hormone Secretagogues.

Review

Sigalos JT, Pastuszak AW · Sexual medicine reviews · 2018

PMID: 28400207

Anecdotes & Sentiment

Public discussion, not clinical evidence

This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.

No curated public-discussion themes are live for Hexarelin yet.

Side Effects & Safety

- Significant cortisol elevation - Prolactin elevation - Rapid desensitization with continuous use (requires cycling) - Water retention - Appetite stimulation (less than GHRP-6)

Significant cortisol elevation
Prolactin elevation
Rapid desensitization with continuous use (requires cycling)
Water retention
Appetite stimulation (less than GHRP-6)

Known Interactions

No curated interaction entry is live for Hexarelin yet.

Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.

Comparison Pages

Comparison pages

All

No comparison page is linked yet.

Frequently Asked Questions

Research Disclaimer

This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.