Epithalon
Epitalon · Epithalamin · AEDG
Popular for:Telomerase activation, anti-aging, pineal gland function
0
Registered Trials
7
Trial Publications
189
PubMed References
Approved
Evidence Level
Overview
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for its effects on telomerase activation and potential anti-aging properties. The short version: people usually care about it for telomerase activation, anti-aging, pineal gland function, but the strength of the evidence depends heavily on indication and study type.
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for its effects on telomerase activation and potential anti-aging properties. It is based on the naturally occurring pineal gland peptide Epithalamin, researched extensively by Russian gerontologist Professor Vladimir Khavinson over several decades.
Khavinson's research suggests that Epithalon may activate telomerase, the enzyme responsible for maintaining telomere length, which is a key biomarker of cellular aging. His studies, primarily conducted in Russia, report effects on lifespan extension in animal models and melatonin normalization.
Research Snapshot
What the evidence says
ApprovedEpithalon currently shows 0 registered trials from ClinicalTrials.gov, 7 PubMed trial publications (5 RCT-tagged), and 189 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 0 registered trials are tracked from ClinicalTrials.gov intervention records.
- 7 PubMed clinical-trial publications are indexed.
- 5 PubMed randomized controlled trial publications are indexed.
- 189 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
Epithalon is studied for its ability to activate telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
International Regulatory Status
0
Registered Trials
7
Trial Publications
5
RCT Publications
189
PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
0
Registered trials
7
Trial publications
5
RCT publications
189
PubMed references
19
Reviews
0
Meta-analyses
Registered trials source
Jun 1, 2026
Epithalon
Uses the exact compound name as a ClinicalTrials.gov intervention query.
View sourcePublication counts source
May 3, 2026
Epithalon, Epitalon, Epithalamin, AEDG
Uses common transliterations and product names for this peptide family.
View sourceNot FDA-approved. Primarily studied in Russian academic research (Khavinson, St. Petersburg Institute of Bioregulation and Gerontology). Limited Western clinical trial data. Research compound.
Key PubMed References
189 PubMed references · showing top 25 by relevance
View all on PubMedTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
PMID: 41490200Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S, Thomas R, Matta S, et al. · Biogerontology · 2025
PMID: 40908429Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, et al. · International journal of molecular sciences · 2025
PMID: 40141333The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Gatta M, Dovizio M, Milillo C, et al. · Stem cell reviews and reports · 2025
PMID: 40493162Peptide Regulation of Cell Differentiation.
Khavinson V, Linkova N, Diatlova A, et al. · Stem cell reviews and reports · 2020
PMID: 31808038Anecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for Epithalon yet.
Side Effects & Safety
- Generally well-tolerated in available research - Injection site reactions - Limited human safety data from Western clinical trials - Long-term effects not fully characterized
Known Interactions
No curated interaction entry is live for Epithalon yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.