Epithalon
Epitalon · Epithalamin · AEDG
Popular for:Telomerase activation, anti-aging, pineal gland function
56
Total Studies
15
Human Studies
Approved
Evidence Level
Not Approved
FDA Status
Overview
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for its effects on telomerase activation and potential anti-aging properties. It is based on the naturally occurring pineal gland peptide Epithalamin, researched extensively by Russian gerontologist Professor Vladimir Khavinson over several decades.
Khavinson's research suggests that Epithalon may activate telomerase, the enzyme responsible for maintaining telomere length, which is a key biomarker of cellular aging. His studies, primarily conducted in Russia, report effects on lifespan extension in animal models and melatonin normalization.
Mechanism of Action
Epithalon is studied for its ability to activate telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase. Telomerase adds repetitive nucleotide sequences to telomeres, the protective caps on chromosomes that shorten with each cell division. Epithalon may also influence pineal gland function and melatonin production, potentially normalizing circadian rhythms that deteriorate with age.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
International Regulatory Status
56
Total Studies
15
Human Studies
Not FDA-approved. Primarily studied in Russian academic research (Khavinson, St. Petersburg Institute of Bioregulation and Gerontology). Limited Western clinical trial data. Research compound.
Key Studies / PubMed References
56 studies found on PubMed · showing top 25 by relevance
View all on PubMedTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
ReviewRahman OF, Lee SJ, Seeds WA · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
PMID: 41490200Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
ReviewAraj SK, Brzezik J, Mądra-Gackowska K, et al. · International journal of molecular sciences · 2025
PMID: 40141333Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
Animal StudyMorozov AV, Khizhkin EA, Svechkina EB, et al. · Bulletin of experimental biology and medicine · 2015
PMID: 26519279[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].
Human StudyDzhokhadze TA, Buadze TZh, Gaĭozishvili MN, et al. · Georgian medical news · 2013
PMID: 24423684Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Animal StudyVinogradova IA, Bukalev AV, Zabezhinski MA, et al. · Bulletin of experimental biology and medicine · 2007
PMID: 18856211Side Effects & Safety
Known Interactions
No curated interaction entry is live for Epithalon yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Epithalon is not approved by the FDA for human therapeutic use. Always consult a qualified healthcare professional before making any health-related decisions. The studies referenced are linked to their original PubMed sources for verification.