Humanin
HN · [Gly14]-Humanin
Popular for:Cytoprotection, neuroprotection, metabolic health
2
Registered Trials
7
Trial Publications
517
PubMed References
Animal
Evidence Level
Overview
Humanin is a mitochondrial-derived peptide (MDP) encoded by the 16S ribosomal RNA gene of mitochondrial DNA. The short version: people usually care about it for cytoprotection, neuroprotection, metabolic health, but the strength of the evidence depends heavily on indication and study type.
Humanin is a mitochondrial-derived peptide (MDP) encoded by the 16S ribosomal RNA gene of mitochondrial DNA. Discovered in 2001 during Alzheimer's disease research, it is a 24-amino acid peptide with potent cytoprotective and neuroprotective effects.
Humanin is part of a family of mitochondrial-derived peptides (including MOTS-c and SHLPs) that act as retrograde signaling molecules from mitochondria to the rest of the cell and body. Circulating humanin levels decline with age and are inversely correlated with age-related diseases.
Research Snapshot
What the evidence says
AnimalHumanin currently shows 2 registered trials from ClinicalTrials.gov, 7 PubMed trial publications (4 RCT-tagged), and 517 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 2 registered trials are tracked from ClinicalTrials.gov intervention records.
- 7 PubMed clinical-trial publications are indexed.
- 4 PubMed randomized controlled trial publications are indexed.
- 517 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
Humanin exerts its cytoprotective effects through multiple mechanisms: it binds to IGFBP-3, modulating the IGF signaling axis; it interacts with BAX, preventing mitochondrial-mediated apoptosis; and it activates the STAT3 signaling pathway.
Key Research Benefits
Clinical Evidence Summary
Research Pipeline
2
Registered Trials
7
Trial Publications
4
RCT Publications
517
PubMed References
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
2
Registered trials
7
Trial publications
4
RCT publications
517
PubMed references
80
Reviews
0
Meta-analyses
Registered trials source
Jun 1, 2026
Humanin
Uses the exact compound name as a ClinicalTrials.gov intervention query.
View sourceNot FDA-approved. Pre-clinical research compound. Discovered 2001. Active area of academic research in aging, neurodegeneration, and metabolic disease.
Key PubMed References
517 PubMed references · showing top 25 by relevance
View all on PubMedThe neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
Alqahtani SM, Al-Kuraishy HM, Al-Gareeb AI, et al. · European journal of pharmacology · 2025
PMID: 40090538Ameliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.
Huang J, Liu Y, Zou L, et al. · Reproductive biomedicine online · 2025
PMID: 40639309Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.
Coradduzza D, Cruciani S, Sibono L, et al. · Clinical and experimental medicine · 2025
PMID: 40768089Impaired Expression of Humanin during Adrenocortical Carcinoma.
Blatkiewicz M, Szyszka M, Olechnowicz A, et al. · International journal of molecular sciences · 2024
PMID: 38256114Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cheng J, Li M, Motta E, et al. · Cell reports. Medicine · 2024
PMID: 39053460Anecdotes & Sentiment
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
No curated public-discussion themes are live for Humanin yet.
Side Effects & Safety
- Very limited human safety data - Research primarily in cell culture and animal models - Long-term effects not characterized - Injection site reactions
Known Interactions
No curated interaction entry is live for Humanin yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.