watchAnecdotalMay 2, 2026
Compounding-list watch
KPV appears in public discussion around proposed peptide compounding reviews, usually alongside BPC-157, TB-500, MOTS-c, Semax, DSIP, and Epithalon.
Reddit / r/medicinemedium confidencereddit
Source KPV
Lys-Pro-Val · alpha-MSH fragment
ImmuneTissue RepairNot ApprovedAnimalResearchSubQOralTopical
Popular for:Anti-inflammatory, gut health, IBD research
0
Registered Trials
0
Trial Publications
65
PubMed References
Animal
Evidence Level
Overview
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). The short version: people usually care about it for anti-inflammatory, gut health, ibd research, but the strength of the evidence depends heavily on indication and study type.
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). It retains the potent anti-inflammatory properties of alpha-MSH without the pigmentation (tanning) side effects, making it a focused anti-inflammatory research compound.
KPV has gained significant attention in the peptide research community for gut health applications, particularly for inflammatory bowel conditions. It can be administered via multiple routes including subcutaneous injection, oral capsules, and topical formulations for skin conditions.
Research Snapshot
What the evidence says
AnimalKPV currently shows 0 registered trials from ClinicalTrials.gov, 0 PubMed trial publications (0 RCT-tagged), and 65 PubMed references matching the stored source query. Treat PubMed references as literature surface area, not a count of clinical trials.
Known vs uncertain
Known signals
- 0 registered trials are tracked from ClinicalTrials.gov intervention records.
- 0 PubMed clinical-trial publications are indexed.
- 0 PubMed randomized controlled trial publications are indexed.
- 65 PubMed references are tracked separately from trial counts and can include animal, in-vitro, review, mechanism, or clinical records.
Open questions
- Evidence strength may vary by indication, route, formulation, and population.
- Public anecdotes can highlight interest or concern but do not establish clinical efficacy.
- Regulatory status and compounding access can change independently from the research literature.
Mechanism of Action
KPV enters cells and travels to the nucleus where it interacts with inflammatory signaling pathways.
Key Research Benefits
Potent anti-inflammatory without tanning side effects
Studied for inflammatory bowel conditions (colitis, IBD)
Researched for skin inflammation and wound healing
Multiple administration routes (oral, SubQ, topical)
Inhibits NF-kB inflammatory pathway
May support gut barrier integrity
Clinical Evidence Summary
Research Pipeline
Preclinical
Animal
Phase I
Phase II
Phase III
Approved
0
Registered Trials
0
Trial Publications
0
RCT Publications
65
PubMed References
ClinicalTrials.govPubMed ESearchExact-name queryChecked May 3, 2026
Registered trials are ClinicalTrials.gov intervention records. Trial publications are PubMed records tagged as clinical trials or randomized controlled trials. PubMed references are broader source-query matches and can include animal studies, in-vitro work, reviews, mechanism papers, and trial publications.
0
Registered trials
0
Trial publications
0
RCT publications
65
PubMed references
8
Reviews
0
Meta-analyses
Registered trials source
Jun 1, 2026
KPV
Uses the exact compound name as a ClinicalTrials.gov intervention query.
View sourceNot FDA-approved. Research compound. Growing body of pre-clinical research, particularly for gut inflammation. Popular in integrative medicine research.
Key PubMed References
65 PubMed references · showing top 25 by relevance
View all on PubMedNLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Human Study
Zeng K, Zhu Y, Han Z, et al. · Cell death and differentiation · 2026
PMID: 40935835Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
In Vitro
Sung J, Ju SY, Park S, et al. · Tissue & cell · 2025
PMID: 40073467KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
In Vitro
Zhang L, Li D, Aierken Y, et al. · Advanced healthcare materials · 2024
PMID: 39252648Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Animal Study
Berr AL, Wiese K, Dos Santos G, et al. · Oncogene · 2023
PMID: 37161053A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.
Animal Study
Zhao Y, Xue P, Lin G, et al. · Acta biomaterialia · 2022
PMID: 35245681Anecdotes & Sentiment
Public discussion, not clinical evidence
This section summarizes what people are talking about in public sources. It can be useful for spotting questions, hype cycles, and recurring concerns, but it is separate from the evidence sections above.
Side Effects & Safety
- Generally well-tolerated in available research - Mild GI discomfort with oral administration - Injection site reactions with SubQ - Limited human clinical trial data
Generally well-tolerated in available research
Mild GI discomfort with oral administration
Injection site reactions with SubQ
Limited human clinical trial data
Known Interactions
No curated interaction entry is live for KPV yet.
Until the interaction table is fully populated, use the interaction checker and related peptides below to explore adjacent compounds and likely research pairings.
Comparison Pages
Comparison pages
AllNo comparison page is linked yet.
Frequently Asked Questions
Research Disclaimer
This page is for research and educational purposes only. The information presented is based on published scientific literature and does not constitute medical advice, diagnosis, or treatment recommendations. Regulatory status can vary by compound, formulation, indication, and jurisdiction. Check official labeling, registry records, and qualified professional guidance before making any health-related decision. The studies referenced are linked to their original PubMed sources for verification.